| San Francisco 49'ers | 0 | 6 | 7 | 9 | - | 22 |
| Indianapolis Colts | 0 | 7 | 3 | 7 | - | 17 |
| Scoring Summary |
|---|
| 2Q: 10:11 IND - Rufus Clinton 17 pass from Norbert Daughtry (Adam Vinatieri extra point) |
| 2Q: 04:12 SFO - Brant Rhodes 45 field goal |
| 2Q: 00:27 SFO - Brant Rhodes 19 field goal |
| 3Q: 07:34 IND - Adam Vinatieri 33 field goal |
| 3Q: 05:40 SFO - Frank Gore 27 run (Brant Rhodes extra point) |
| 4Q: 04:33 SFO - Brant Rhodes 37 field goal |
| 4Q: 01:30 SFO - Frank Gore 1 run (Harvey Lapuente run for conversion failed) |
| 4Q: 00:40 IND - Brandon Stokley 7 pass from Norbert Daughtry (Adam Vinatieri extra point) |
| Team Statistics | SFO | IND |
|---|---|---|
| Record | 1-0 | 0-1 |
| First Downs | 14 | 17 |
| - by Rushing | 6 | 6 |
| - by Passing | 8 | 11 |
| - by Penalty | 0 | 0 |
| Total Net Yards | 334 | 314 |
| - Offensive Plays | 57 | 68 |
| - Yards per Play | 5.86 | 4.62 |
| Net Rushing Yards | 111 | 92 |
| - Rushing Attempts | 18 | 22 |
| - Yards per Rush | 6.17 | 4.18 |
| Net Passing Yards | 223 | 222 |
| - Att./Comp./Intrcpt | 37 - 22 - 3 | 38 - 26 - 2 |
| - Gross Passing Yards | 237 | 288 |
| - Sacks/Yards Lost | 2/14 | 8/66 |
| - Yards per Pass Play | 5.72 | 4.83 |
| Fumbles/Lost | 1/1 | 4/2 |
| 3rd Down Conversions | 3/11 | 6/15 |
| - Avg. YtG on 3rd Down | 8.7 | 8.7 |
| 4th Down Conversions | 0/0 | 0/1 |
| Penalties/Yards | 7/55 | 4/40 |
| Punt Returns/Yards | 0/0 | 1/17 |
| Kick Returns/Yards | 3/62 | 6/116 |
| Interception Ret./Yards | 2/17 | 3/1 |
| 2pt Conversions | 1/0 | 0/0 |
| Red Zone Visits | 2 | 3 |
| - Red Zone TDs/FGs | 1/1 | 2/1 |
| Avg. Drive Start | OWN 35 | OWN 33 |
| Time of Possession | 25:40 | 34:20 |
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